阿德福韦酯
基本信息
| 产品名称 | 阿德福韦酯 |
|---|---|
| 英文名称 | Adefovir Dipivoxil |
| 别名 | 阿德伏韦酯;阿德幅韦二脂 |
| 英文别名 | 9-(2[bis(Pivaloyloxymethoxy)phosphorylmethoxy]ethyl)adenine |
| 规格或纯度 | ≥99% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | 强大的，选择性的核苷酸类似物逆转录酶抑制剂。抑制病毒DNA合成（IC 50 = 0.2-2.5μM，HBV转染的人肝癌细胞系）。在体内显示抗病毒作用。口服具有活性 |
一般描述
Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Target: NRTIs; HBV Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4].
Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Target: NRTIs; HBV Adefovir Dipivoxil works by blocking reverse transcriptase, an enzyme that is crucial for the hepatitis B virus (HBV) to reproduce in the body. Adefovir Dipivoxil is used for treatment of hepatitis B and herpes simplex virus infection [1-3]. Adefovir Dipivoxil is approved for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (primarily ALT) or histologically active disease. Adefovir Dipivoxil is a failed treatment for HIV[3, 4].
Catalyst employed in the Sharpless Asymmetric Dihyroxylation of (E,E)- or (E,Z)-1,3-dienoates.1 Also used in the preparation of ?-hydroxy-γ-lactones from ?,γ-unsaturated esters.2
相关属性
| CAS编号 | 142340-99-6 |
|---|---|
| 敏感性 | 对热敏感 |
| 熔点 | 101 °C |
| 溶解性 | DMSO : ≥ 100 mg/mL (199.41 mM) H2O : 0.67 mg/mL (1.34 mM; Need ultrasonic) |
| 储存温度 | -20°C储存 |
| Reaxys-RN | 7060608 |
| RTECS | UA2459362 |
| MDL号 | MFCD00869897 |
| 分子量 | 501.47 |
| 分子式 | C20H32N5O8P |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 60871 |