Dinactin
抑制IL-2诱导的T细胞增殖的疏水性环状酯
>95%
有货
基本信息
| 产品名称 | Dinactin |
|---|---|
| 英文名称 | Dinactin |
| 英文别名 | Antibiotic AKD 1C; Antibiotic S 3466A |
| 规格或纯度 | >95% |
| 运输条件 | 冰袋运输 |
一般描述
Dinactin是最初由金黄色链霉菌生产的疏水性环状酯。它充当抗生素和阳离子离子载体，对铵离子和钾离子具有高选择性。据报道，Dinactin抑制由IL-2（白介素2）诱导的T细胞增殖。另外，该化合物显示出抑制IC 50为10 ng / ml的细胞因子的产生。机理研究表明，dinactin通过转录后机制抑制细胞因子的产生。
Dinactin is a hydrophobic cyclic ester originally produced by|Streptomyces aureus|. It acts as an antibiotic and cation ionophore, with high selectivity for ammonium and potassium ions. Dinactin has been reported to inhibit T-cell proliferation induced by IL-2 (interleukin-2). Additionally, this compound has been shown to inhibit cytokine production with IC|50|values of 10 ng/ml. Mechanistic studies suggest that dinactin inhibits cytokine production through a post-transcriptional mechanism.
相关属性
| CAS编号 | 20261-85-2 |
|---|---|
| 折光率 | n20D1.45 (Predicted) |
| 沸点 | 903.25° C at 760 mmHg (Predicted) |
| 溶解性 | Soluble in ethyl acetate, DMSO, 100% ethanol (moderately ), and methanol (moderately ). |
| 储存温度 | 2-8°C储存 |
| 密度 | 1.03 g/cm3(Predicted) |
| 分子量 | 764.98 |
| 分子式 | C42H68O12 |
| 品牌 | Jinpan |
| Smiles | CCC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)CC)C)C)C |
| PubChem CID | 248000 |