Cas(58880-19-6), Trichostatin A, TSA;曲古抑菌素 A,Trichostatin A,

发表于由

曲古柳菌素A

高效的选择性组蛋白脱乙酰基酶抑制剂
≥98%

有货

Cas(58880-19-6), Trichostatin A, TSA;曲古抑菌素 A,Trichostatin A,

CAS编号 58880-19-6 | 品牌：Jinpan
Trichostatin A

MSDS

质检证书(CoA)

相似产品

  • 分子式 C17H22N2O3
  • 分子量302.37
  • MDL号 MFCD03848392
  • PubChem编号 444732

货号 (SKU) 包装规格 是否现货 价格 数量
T129665-1mg 1mg 现货 Cas(58880-19-6), Trichostatin A, TSA;曲古抑菌素 A,Trichostatin A,  
T129665-5mg 5mg 现货 Cas(58880-19-6), Trichostatin A, TSA;曲古抑菌素 A,Trichostatin A,  
T129665-10mg 10mg 现货 Cas(58880-19-6), Trichostatin A, TSA;曲古抑菌素 A,Trichostatin A,  
T129665-25mg 25mg 期货 Cas(58880-19-6), Trichostatin A, TSA;曲古抑菌素 A,Trichostatin A,  
T129665-50mg 50mg 期货 Cas(58880-19-6), Trichostatin A, TSA;曲古抑菌素 A,Trichostatin A,  

基本信息

产品名称 曲古柳菌素A
英文名称 Trichostatin A
别名 TSA;曲古抑菌素 A
英文别名 TSA; R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
应用 A potent and non-competitive reversible inhibitor of HDAC.
规格或纯度 ≥98%
运输条件 超低温冰袋运输
生化机理 Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of histone deacetylases (HDAC) with a Ki of 3.4 nM. In HeLa cells, TSA blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin. In cells latently infected with HIV-1, TSA induced the transcriptional activation of the HIV-1 promoter, which resulted in a marked increase in virus production. In NIH 3T3 cells, TSA induced reversion of oncogenic ras-transformed cells to a normal morphology. In Jurkat cells, TSA inhibited IL-2 gene expression and displayed immunosuppressive activity in a mouse model. Induces increased acetylation of GATA4, a cardiac-specific transcription factor and increases cardiac muscle cell differentiation. In normal fibroblasts, induced Friend cell differentiation and inhibited the G1 and G2 phases of the cell cycle.Potent, selective histone deacetylase (HDAC) inhibitor (K i = 3.4 nM). Induces cell proliferation, differentiation and apoptosis in vitro . Anticancer and antifungal agent. Active in vivo and in vitro .

一般描述

Trichostatin A (TSA)是一种HDAC抑制剂，IC50为1.8 nM左右，HDAC8是HDAC家族中唯一不受TSA影响的成员。A potent and non-competitive reversible inhibitor of HDAC.

Trichostatin A (TSA) is an HDAC inhibitor with IC50 of ~1.8 nM – HDAC8 is the only known member of the HDAC-family that is not affected by TSA.
A potent and non-competitive reversible inhibitor of HDAC.

相关属性

CAS编号 58880-19-6
敏感性 对热敏感
比旋光度 136° (C=0.3,MeOH)
熔点 144 °C(dec.)
溶解性 Soluble in water (Partly Miscible), ethanol (2 mg/mL), DMSO (20 mg/mL), acetonitrile, DMF (30 mg/mL), and methanol
储存温度 -20°C储存
Reaxys-RN 2391788
RTECS MI5215000
MDL号 MFCD03848392
分子量 302.37
分子式 C17H22N2O3
品牌 Jinpan
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PubChem CID 444732