衣霉素
基本信息
| 产品名称 | 衣霉素 |
|---|---|
| 英文名称 | Tunicamycin |
| 别名 | 链病毒菌素 |
| 英文别名 | Tunicamycin fromStreptomycessp. |
| 应用 | A competitive cell cycle inhibitor |
| 规格或纯度 | 98% |
| 运输条件 | 超低温冰袋运输 |
| 生化机理 | Antibacterial and antifungal. Blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Inhibits bacterial and eukaryote N-acetylglucosamine transferases and prevents formation of N-acetylglucosamine lipid intermediates.Nucleoside antibiotic that inhibits protein glycosylation. Inhibits GlcNAc phosphotransferase (GPT) and inhibits the transfer of N -acetylglucosamine-1-phosphate from UDP- N -acetylglucosamine to dolichol phosphate in the first step of glycoprotein synthe |
一般描述
Tunicamycin is a mixture of Tunicamycins A, B, C and D which has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GNPTAB (GlcNAc phosphotransferase, GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein synthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, to inhibit protein glycosylation, to suppress the S-phase of the cell cycle, and to arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, this compound is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.A competitive cell cycle inhibitor
Tunicamycin is a mixture of Tunicamycins A, B, C and D which has been widely used in the study of glycoprotein synthesis in various biological systems. Tunicamycin inhibits GNPTAB (GlcNAc phosphotransferase, GPT) and inhibts the formation of N-glycosidic linkages in glycoprotein synthesis. Tunicamycin has also been reported to have a dose-dependent inhibition of DNA synthesis, to inhibit protein glycosylation, to suppress the S-phase of the cell cycle, and to arrest the cell cycle in late G1. As a member of a family of antibiotics produced by Streptomyces lysosuperficus, this compound is noted to be active in vitro against gram-positive bacteria, fungi, yeasts and viruses. During protein glycosylation, tunicamycin is noted to be an inhibitor of the transfer of saccharide moieties to dolichol during dolichol-linked glycoprotein synthesis. Dose-dependent inhibition of DNA synthesis may be related to the alteration of glycoproteins, which thereby affects the transport of thymidine into cells. Additionally, tunicamycin has been reported to prevent cell cycle progression in primary cultures of rat glial cells, as well as inhibit lipid-mediated protein glycosylation in chick or mouse fibroblasts in a dose-dependent manner.
A competitive cell cycle inhibitor
相关属性
| CAS编号 | 11089-65-9 |
|---|---|
| 敏感性 | 对湿度敏感； 对光敏感 |
| 溶解性 | Soluble in water (partly miscible), alkaline water, pyridine, hot methanol, DMSO (>10 mg/ml), ethanol (5 mg/ml, warm), butanol (slightly), and DMF. Insoluble in acetone, ethyl acetate, chloroform, benzene, and acidic water. |
| 储存温度 | 避光,-20°C储存 |
| RTECS | YO7980200 |
| MDL号 | MFCD00065709 |
| 密度 | 1.57 |
| 分子量 | 844.95 |
| 分子式 | C39H64N4O16 (for n=10, “Tunicamycin VII”) |
| 品牌 | Jinpan |
| 备注 | 如果有可能，您尽量在同一天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。有毒，请参阅SDS以获取更多信息。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。 |
| PubChem CID | 341109781 |