上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
KDOAM-25 citrate 纯度: 95.46%
KDOAM-25 citrate 是有效,高选择性的组蛋白赖氨酸脱甲基酶 5 (KDM5) 抑制剂,对 KDM5A,KDM5B,KDM5C,KDM5D 的 IC50 分别为 71 nM,19 nM,69 nM,69 nM。KDOAM-25 citrate 可增加转录起始位点的整体 H3K4 甲基化,并损害多发性骨髓瘤 MM1S 细胞的增殖。
KDOAM-25 citrate Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥1100 | In-stock | |
5 mg | ¥1000 | In-stock | |
10 mg | ¥1800 | In-stock | |
50 mg | ¥7000 | In-stock | |
100 mg | ¥13000 | In-stock | |
200 mg | ¥24000 | In-stock | |
500 mg | ¥45000 | In-stock | |
1 g | 询价 | ||
5 g | 询价 |
* Please select Quantity before adding items.
KDOAM-25 citrate 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Epigenetics Compound Library
- Histone Modification Research Compound Library
- Anti-Cancer Compound Library
- Anti-Blood Cancer Compound Library
- Transcription Factor Targeted Library
- Targeted Diversity Library
生物活性 |
KDOAM-25 citrate is a potent and highly selective histone lysine demethylases 5 (KDM5) inhibitor with IC50s of 71 nM, 19 nM, 69 nM, 69 nM for KDM5A, KDM5B, KDM5C, KDM5D, respectively. KDOAM-25 citrate increases global H3K4 methylation at transcriptional start sites and impairs proliferation in multiple myeloma MM1S cells[1]. |
IC50 & Target |
IC50: 71 nM (KDM5A), 19 nM (KDM5B), 69 nM (KDM5C), 69 nM (KDM5D)[1] |
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体外研究 (In Vitro) |
KDOAM-25 citrate inhibits most potently KDM5B with an IC50 of ∼50 μM and the other KDM5 family members at concentrations above 100 μM. KDOAM-25 citrate shows no cellular activity on any of the other tested JmjC family members[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
499.51 |
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Formula |
C21H33N5O9 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) |
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溶解性数据 |
In Vitro:
DMSO : 200 mg/mL (400.39 mM; Need ultrasonic) H2O : 100 mg/mL (200.20 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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