6-Diazo-5-oxo-L-nor-Leucine(Synonyms: L-6-Diazo-5-oxonorleucine; DON)

发表于由

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6-Diazo-5-oxo-L-nor-Leucine (Synonyms: L-6-Diazo-5-oxonorleucine; DON) 纯度: 99.92%

L-6-Diazo-5-oxonorleucine (L-6-Diazo-5-oxonorleucine) 是一种谷氨酰胺拮抗剂，其Ki 值为 6 μM。L-6-Diazo-5-oxonorleucine 具有抗菌、抗病毒和抗癌作用。L-6-Diazo-5-oxonorleucine 在体外表现出遗传毒性。L-6-Diazo-5-oxonorleucine 能降低肿瘤细胞的自我更新能力和转移能力 。

6-Diazo-5-oxo-L-nor-Leucine(Synonyms: L-6-Diazo-5-oxonorleucine; DON)

6-Diazo-5-oxo-L-nor-Leucine Chemical Structure

CAS No. : 157-03-9

规格 价格 是否有货 数量
10 mM * 1 mL in Water ￥5271 In-stock
1 mg ￥2800 In-stock
5 mg ￥3850 In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

6-Diazo-5-oxo-L-nor-Leucine 相关产品

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生物活性

L-6-Diazo-5-oxonorleucine (L-6-Diazo-5-oxonorleucine) is a glutaminases antagonist with a Ki of 6 μM. L-6-Diazo-5-oxonorleucine exhibits antibacterial, antiviral and anticancer properties. L-6-Diazo-5-oxonorleucine displays genetic toxicity in vitro. L-6-Diazo-5-oxonorleucine decreases the self-renewal potential and metastatic ability of tumor cell[1][2][3][4].

IC50 & Target

Ki: 6 μM (glutaminases)[4]
分子量

171.15

Formula

C6H9N3O3
CAS 号

157-03-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 50 mg/mL (292.14 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.8428 mL 29.2141 mL 58.4283 mL
5 mM 1.1686 mL 5.8428 mL 11.6857 mL
10 mM 0.5843 mL 2.9214 mL 5.8428 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kulkarni RM, et al. Evaluation of genetic toxicity of 6-diazo-5-oxo-l-norleucine (DON). Toxicol Mech Methods. 2017 Sep;27(7):518-527.

    [2]. Thangavelu K, et al. Structural basis for the active site inhibition mechanism of human kidney-type glutaminase (KGA). Sci Rep. 2014 Jan 23;4:3827.

    [3]. Willis RC, et al. The inhibition by 6-diazo-5-oxo-l-norleucine of glutamine catabolism of the cultured human lymphoblast. J Cell Physiol. 1977 Dec;93(3):375-82.

    [4]. Sharma NS, et al. Targeting tumor-intrinsic hexosamine biosynthesis sensitizes pancreatic cancer to anti-PD1 therapy. J Clin Invest. 2019 Oct 15.

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