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Cordycepin (Synonyms: 虫草素; 3′-Deoxyadenosine) 纯度: ≥99.0%
Cordycepin (3′-Deoxyadenosine) 是一种核苷衍生物,在类风湿性关节炎滑膜成纤维细胞 (RASF) 中,抑制 IL-1β 诱导的 MMP-1 和 MMP-3 表达,这种作用存在剂量依赖性。Cordycepin 通过抑制细菌的腺苷激酶杀死结核分枝杆菌。
Cordycepin Chemical Structure
CAS No. : 73-03-0
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥715 | In-stock | |
10 mg | ¥650 | In-stock | |
25 mg | ¥1430 | In-stock | |
50 mg | ¥2450 | In-stock | |
100 mg | ¥4160 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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生物活性 |
Cordycepin (3′-Deoxyadenosine) is a nucleoside derivative and inhibits IL-1β-induced MMP-1 and MMP-3 expression in rheumatoid arthritis synovial fibroblasts (RASFs) in a dose-dependent manner[1]. Cordycepin kills Mycobacterium tuberculosis through hijacking the bacterial adenosine kinase[2]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Cordycepin is a potent inhibitor of IL-1β-induced chemokine production and MMP expression and strongly blocks the p38/JNK/AP-1 signalling pathway in RASFs. The effect of Cordycepin on cellular toxicity of RASFs is assessed using MTT assay. Treatment of RASFs with Cordycepin (50 μM or 100 μM) for 24 h does not cause any significant change in cell viability. However, cell viability is slightly decreased when cells are incubated with 100 μM Cordycepin for 48 h[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
251.24 |
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Formula |
C10H13N5O3 |
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CAS 号 |
73-03-0 |
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中文名称 |
虫草素;蛹虫草菌素;冬虫夏草菌素;3′-脱氧腺苷;虫草多糖 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (199.01 mM; Need ultrasonic) H2O : 2 mg/mL (7.96 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [1] |
RASFs (2×104 cells/well) are treated with various concentrations of Cordycepin (50 μM or 100 μM). After incubation for 1 h, 12 h and 24 h, cells are washed twice with PBS, MTT (0.5 mg/mL PBS) is added to each well and incubated at 37°C for 30 min. Formazan crystals formed are dissolved by adding DMSO (100 μL/well) and the absorbance is read at 570 nm using a microplate reader[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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参考文献 |
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