Ammonium iron(III) citrate(Synonyms: 柠檬酸铁 (III) 铵; Ammonium ferric citrate; FAC)

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Ammonium iron(III) citrate (Synonyms: 柠檬酸铁 (III) 铵; Ammonium ferric citrate; FAC) 纯度: ≥95.0%

Ammonium iron(III) citrate (Ammonium ferric citrate) 是一种非运铁蛋白结合的铁的生理形式,会引起的细胞内铁超负荷从而导致细胞铁死亡 (ferroptosis)。Ammonium iron(III) citrate 可以增强蛋白质的产生。

Ammonium iron(III) citrate(Synonyms: 柠檬酸铁 (III) 铵; Ammonium ferric citrate;  FAC)

Ammonium iron(III) citrate Chemical Structure

CAS No. : 1185-57-5

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生物活性

Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis[1]. Ammonium iron(III) citrate can enhance protein production[2].

体外研究
(In Vitro)

Ammonium iron(III) citrate (Ammonium ferric citrate; 1, 5, 10, 15 mM; 24 hours) with 5 mM induces cell death in HT1080 cells. AML12 cells were highly resistant to Ammonium iron(III) citrate, as they maintained cell viability about 80%. Ammonium iron(III) citrate can be actively transported into cells by specific transporter[1].
Ammonium iron(III) citrate (6, 12, 18 mg/L) has a higher biomas for Chlorella vulgaris FSP-E (CV) in BG-11 medium with 12 mg/L and 18 mg/L[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Formula

C6H8O7.xFe.xNH3

CAS 号

1185-57-5

中文名称

柠檬酸铁 (III) 铵

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 33.33 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (ultrasonic) (insoluble or slightly soluble)

参考文献
  • [1]. Shenglin Fang, et al. Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. Biochem Biophys Res Commun. 2018 Sep 3;503(1):297-303.

    [2]. Yu-Cheng Lai, et al. Towards protein production and application by using Chlorella species as circular economy. Bioresour Technol. 2019 Oct;289:121625.

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