上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Piperlongumine (Synonyms: 荜茇酰胺; Piplartine) 纯度: 98.23%
Piperlongumine 是一种生物碱,具有抗炎、抗菌、抗血管生成、抗氧化、抗肿瘤和抗糖尿病等活性。在肿瘤细胞中,Piperlongumine 能够诱导 ROS 和凋亡。Piperlongumine 具有抗心肌纤维化的作用,通过抑制 ERK1/2 信号通路抑制肌成纤维细胞的转化。
Piperlongumine Chemical Structure
CAS No. : 20069-09-4
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
10 mM * 1 mL in DMSO | ¥550 | In-stock | |
10 mg | ¥500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
* Please select Quantity before adding items.
Piperlongumine 相关产品
•相关化合物库:
- Covalent Screening Library Plus
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Anti-Infection Compound Library
- Apoptosis Compound Library
- Immunology/Inflammation Compound Library
- Kinase Inhibitor Library
- MAPK Compound Library
- Metabolism/Protease Compound Library
- NF-κB Signaling Compound Library
- Stem Cell Signaling Compound Library
- Natural Product Library
- Anti-Cancer Compound Library
- Autophagy Compound Library
- Anti-Aging Compound Library
- Covalent Screening Library
- Antioxidants Compound Library
- Reprogramming Compound Library
- Diabetes Related Compound Library
- Oxygen Sensing Compound Library
- Anti-Cardiovascular Disease Compound Library
- Antibacterial Compound Library
- Ferroptosis Compound Library
- Medicine Food Homology Compound Library
- Pyroptosis Compound Library
- Glutamine Metabolism Compound Library
- Traditional Chinese Medicine Monomer Library
- Alkaloids Library
- Anti-Pancreatic Cancer Compound Library
- Anti-Obesity Compound Library
- Angiogenesis Related Compound Library
- Mitochondria-Targeted Compound Library
- Anti-Liver Cancer Compound Library
- Anti-Colorectal Cancer Compound Library
生物活性 |
Piperlongumine is a alkaloid[1], possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities[2]. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines[1]. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway[2]. |
||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target[2] |
|
||||||||||||||||
体外研究 (In Vitro) |
Piplartine (5, 10, and 15 μM) significantly decreases cell proliferation of 786-O, SKBR3, Panc1, A549, and L3.6pL cancer cells after treatment for 24 and 48 hours, induces apoptosis and ROS in these cell lines at 5 and 10 μM after 3 or 9 h of treatment[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
体内研究 (In Vivo) |
Piperlongumine (30 mg/kg/day, i.p. for 3 weeks) exhibits potent anti-tumor effect in athymic nude mice bearing L3.6pL cells without body weight loss[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||||||
分子量 |
317.34 |
||||||||||||||||
Formula |
C17H19NO5 |
||||||||||||||||
CAS 号 |
20069-09-4 |
||||||||||||||||
中文名称 |
荜茇酰胺 |
||||||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||||||
储存方式 |
|
||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (315.12 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
|
||||||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务