L-Asparaginase(Synonyms: L-​ASNase)

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L-Asparaginase (Synonyms: L-​ASNase) 纯度: ≥99.0%

L-Asparaginase (L-​ASNase) 是一种催化 L-天冬酰胺转化的水解酶,用于急性淋巴细胞白血病的研究。L-asparaginase 从血浆中去除 L-天冬酰胺会导致 RNA 和 DNA 合成抑制,随后引起细胞凋亡。

L-Asparaginase(Synonyms: L-​ASNase)

L-Asparaginase Chemical Structure

CAS No. : 9015-68-3

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L-Asparaginase 相关产品

相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

L-Asparaginase (L-​ASNase), a hydrolase that catalyzes the conversion of L-asparagine, used in acute lymphoblastic leukemia treatment. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis[1].

Clinical Trial

CAS 号

9015-68-3

中文名称

L-天门冬酰胺酶

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Protect from light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

0.1 M HCL : 50 mg/mL (ultrasonic and adjust pH to 3 with HCl)

H2O : < 0.1 mg/mL (insoluble)

参考文献
  • [1]. Piatkowska-Jakubas B, et al. Use of L-asparaginase in acute lymphoblastic leukemia: recommendations of the Polish Adult Leukemia Group. Pol Arch Med Wewn. 2008 Nov;118(11):664-9.

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