Sodium orthovanadate(Synonyms: 钒酸钠)

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Sodium orthovanadate (Synonyms: 钒酸钠) 纯度: ≥99.0%

Sodium orthovanadate是蛋白酪氨酸磷酸酶，碱性磷酸酶和一些ATP酶的抑制剂，最有可能充当磷酸盐类似物。

Sodium orthovanadate(Synonyms: 钒酸钠)

Sodium orthovanadate Chemical Structure

CAS No. : 13721-39-6

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10 mM * 1 mL in Water ￥500 In-stock
500 mg ￥400 In-stock
5 g ￥500 In-stock
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Sodium orthovanadate 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Anti-Cancer Compound Library
  • Oxygen Sensing Compound Library
  • Phosphatase Inhibitor Library

生物活性

Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.

IC50 & Target

PPTPase[1].
体外研究
(In Vitro)

In the presence of oxidizing agents vanadium ions exist as the hydrated monomer of Sodium orthovanadate (vanadate: HVO42- or H2VO4-) at micromolar concentations near neutral pH. Sodium orthovanadate (vanadate) also begins to polymerize at concentrations greater than 0.1 mM at neutral pH. The yellow-orange solutions of decavanadate can be converted to the colorless solutions of monomeric Sodium orthovanadate (vanadate) by dilution after a period of many hours. The process is hastened by boiling at pH 10, which encourages the kinetically sluggish depolymerization process[1]. Sodium orthovanadate could alter the phosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia. Sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK1 via activating Akt during cerebral ischemia[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

183.91

Formula

Na3O4V
CAS 号

13721-39-6
中文名称

正钒酸钠；原钒酸钠；钒酸钠
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 8.33 mg/mL (45.29 mM; Need ultrasonic)

DMSO : 1 mg/mL (5.44 mM; ultrasonic and warming and heat to 80°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.4374 mL 27.1872 mL 54.3744 mL
5 mM 1.0875 mL 5.4374 mL 10.8749 mL
10 mM 0.5437 mL 2.7187 mL 5.4374 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Gordon JA, et al. Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol. 1991;201:477-82.

    [2]. Wu DN, et al. Down-regulation of PTEN by sodium orthovanadate inhibits ASK1 activation via PI3-K/Akt during cerebral ischemia in rat hippocampus. Neurosci Lett. 2006 Aug 14;404(1-2):98-102.

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