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Eicosapentaenoic Acid (Synonyms: 二十碳五烯酸; EPA; Timnodonic acid) 纯度: ≥95.0%
Eicosapentaenoic Acid (EPA) 是一种具有口服活性的 ω-3 长链多不饱和脂肪酸 (ω-3 LC-PUFAs)。Eicosapentaenoic Acid 具有促进肿瘤抑制基因 CCAAT/增强子结合蛋白δ (C/EBPδ) 重新表达的 DNA 去甲基化作用。Eicosapentaenoic Acid 通过 H-RAS 内含子 1 CpG 岛去甲基化激活U937 白血病细胞中的 RAS/ERK/C/EBPβ 途径。Eicosapentaenoic Acid 能促进血管平滑肌细胞的松弛和血管舒张。
Eicosapentaenoic Acid Chemical Structure
CAS No. : 10417-94-4
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥605 | In-stock | |
50 mg | ¥550 | In-stock | |
100 mg | ¥750 | In-stock | |
500 mg | ¥3000 | In-stock | |
1 g | 询价 | ||
5 g | 询价 |
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生物活性 |
Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3]. |
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IC50 & Target |
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体外研究 (In Vitro) |
C/EBPβ phosphorylated form is evident in Eicosapentaenoic Acid (EPA; 100 µM; 24 h) treated cells, whereas it was barely detectable in control, and OA or LA treated U937[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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Clinical Trial |
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分子量 |
302.45 |
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Formula |
C20H30O2 |
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CAS 号 |
10417-94-4 |
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中文名称 |
二十碳五烯酸 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
Ethanol : ≥ 100 mg/mL (330.63 mM) DMSO : ≥ 53 mg/mL (175.24 mM) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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