卡那霉素 硫酸酯 来源于卡那霉素链霉菌
基本信息
| 产品名称 | 卡那霉素 硫酸酯 来源于卡那霉素链霉菌 |
|---|---|
| 英文名称 | Kanamycin sulfate from Streptomyces kanamyceticus |
| 别名 | 卡那霉素 A, 卡那霉素碱 硫酸盐 |
| 英文别名 | Kanamycin sulfate salt, Kanamycin A |
| 规格或纯度 | 不含动物成分 |
| 生化机理 | 作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。 耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。 抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。 |
一般描述
制备说明
Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.
General Description
Chemical structure: aminoglycoside
Application
Kanamycin sulfate is a broad spectrum aminoglycoside-antibiotic derived from Streptomyces kanamyceticus . It is used as an additive in culture media for the isolation of group D streptococci on Kanamycin Esculin Azide Agar and for selection of transformed plant cells containing the neomycin phosphotransferase on a kanamycin-medium. Kanamycin sulfate can also be used as a selection agent for cells transformed with kanamycin B resistance gene. It is recommended for use in cell culture applications at 100 μg/mL.
相关属性
| CAS编号 | 25389-94-0 |
|---|---|
| 比旋光度 | 117.5 ° (C=1, H2O) |
| 熔点 | 250°C(dec.)(lit.) |
| 溶解性 | H2O：50mg/mL，清澈，无色至淡黄色 |
| Reaxys-RN | 3874279 |
| RTECS | NZ3225030 |
| 分子量 | 582.58 |
| 分子式 | C18H36N4O11·H2SO4 |
| 品牌 | Jinpan |
| 备注 | 注意: Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage. |
| Smiles | ;OC[C@H]1O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@@H](O)[C@H]3O)[C@H]2O)[C@H](O)[C@H](N)[C@@H]1O;OC[C@H]1O[C@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]2O)[C@H](O)[C@@H](N)[C@@H]1O.OS(=O)(=O |
| 关联CAS | 70560-51-9 |
| PubChem CID | 441374 |