利福昔明
基本信息
| 产品名称 | 利福昔明 |
|---|---|
| 英文名称 | Rifaximin |
| 英文别名 | 4-Deoxy-4′-methylpyrido[1′,2′-1,2]imidazo[5,4-c]rifamycin SV, Rifacol |
一般描述
Description
Chemical structure: macrolideRifaximin is a semisynthetic analog of rifamycin with poor absorptivity. It selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by a mechanism similar to rifabutin, β subunit binding. It is effective against aerobic and anaerobic Gram-positive and Gram-negative bacteria. It is active against species ofStaphylococcus,StreptococcusandEnterococcus. It is less active against species ofEnterobacteriaceae. Rifaximin is a non-systemic, gastrointestinal site-specific antibiotic. It has a pyridoimidazole ring, making it non-absorbable. Rifaximin is a pregnane X receptor (PXR) activator.
Preparation instructions
Practically insoluble in water, soluble in acetone and methanol.
Description
Chemical structure: macrolideRifaximin is a semisynthetic analog of rifamycin with poor absorptivity. It selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by a mechanism similar to rifabutin, β subunit binding. It is effective against aerobic and anaerobic Gram-positive and Gram-negative bacteria. It is active against species ofStaphylococcus,StreptococcusandEnterococcus. It is less active against species ofEnterobacteriaceae. Rifaximin is a non-systemic, gastrointestinal site-specific antibiotic. It has a pyridoimidazole ring, making it non-absorbable. Rifaximin is a pregnane X receptor (PXR) activator.
Preparation instructions
Practically insoluble in water, soluble in acetone and methanol.
相关属性
| CAS编号 | 80621-81-4 |
|---|---|
| 熔点 | 212 °C |
| 储存温度 | 干燥 |
| MDL号 | MFCD00864973 |
| 分子量 | 785.88 |
| 分子式 | C43H51N3O11 |
| 品牌 | Jinpan |
| PubChem CID | 6436173 |