伊曲康唑
基本信息
| 产品名称 | 伊曲康唑 |
|---|---|
| 英文名称 | Itraconazole |
| 英文别名 | Sporanox, R51211, Oriconazole |
| 规格或纯度 | ≥98% (TLC) |
| 运输条件 | 冰袋运输 |
| 生化机理 | 伊曲康唑抑制细胞色素 P-450 依赖性酶，从而抑制麦角固醇的合成。它通过与 14-α 脱甲基酶相互作用来实现该抑制作用，14-α 脱甲基酶是将羊毛甾醇转化为麦角固醇所必需的细胞色素 P-450 酶。麦角固醇是真菌细胞膜的重要组成部分。因此，它的抑制作用导致细胞通透性增加，造成细胞内容物外泄。伊曲康唑还可能抑制内源性呼吸、与膜磷脂相互作用、抑制酵母转化为菌丝体形式、抑制嘌呤摄取，并减少甘油三酸酯和磷脂的生物合成。 |
一般描述
Description
Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It′s different formulations are used to studyCandidastrains in murine invasive infections. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats.
Description
Itraconazole is a triazole antifungal agent. It is used to inhibit cytochrome P-450-dependent enzymes and ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis, and aspergillosis. It′s different formulations are used to studyCandidastrains in murine invasive infections. It has been used to study proliferative changes of the forestomach mucosa in alloxan-induced diabetic rats.
相关属性
| CAS编号 | 84625-61-6 |
|---|---|
| 熔点 | 167.0 to 171.0 °C |
| 溶解性 | 氯仿：50mg/mL，透明，无色 |
| 储存温度 | 2-8°C储存 |
| Reaxys-RN | 6042047 |
| RTECS | XZ5481000 |
| MDL号 | MFCD00870168 |
| 分子量 | 705.63 |
| 分子式 | C35H38Cl2N8O4 |
| 品牌 | Jinpan |
| PubChem CID | 3793 |