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GSK2795039 纯度: 99.71%
GSK2795039 是一种 NADPH 氧化酶 2 (NOX2) 抑制剂,在不同的无细胞试验中平均 pIC50 为 6。GSK2795039 抑制活性氧 (Reactive Oxygen Species) 产生和 NADPH 消耗,同时可减少细胞凋亡 (apoptosis)。
GSK2795039 Chemical Structure
CAS No. : 1415925-18-6
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥3190 | In-stock | |
5 mg | ¥2900 | In-stock | |
10 mg | ¥4200 | In-stock | |
25 mg | ¥8400 | In-stock | |
50 mg | ¥13400 | In-stock | |
100 mg | ¥21500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
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GSK2795039 相关产品
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生物活性 |
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC50 of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption[1]. GSK2795039 reduces apoptosis[2]. |
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体外研究 (In Vitro) |
GSK2795039 (25 μM; 24 hours) reduces the combinatory effect of FeSO4 and LPS-increased levels of apoptosis and reduced the presence of caspase-3-positive PC12 cells[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. Apoptosis Analysis[2]
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体内研究 (In Vivo) |
GSK2795039 (intraperitoneal injection; 100 mg/kg; 1 hour before) decreases activity in a murine model of acute pancreatitis, reducing the levels of serum amylase triggered by systemic injection of cerulein[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
450.56 |
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Formula |
C23H26N6O2S |
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CAS 号 |
1415925-18-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (221.95 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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