Imiquimod(Synonyms: 咪喹莫特; R 837)

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Imiquimod (Synonyms: 咪喹莫特; R 837) 纯度: 99.96%

Imiquimod (R 837) 是一种 toll 样受体7 (TLR7) 激动剂，作为一种免疫反应修饰剂。Imiquimod 在体内表现出抗病毒和抗肿瘤作用。Imiquimod 可用于外生殖器、肛周疣、癌症和 COVID-19 的研究。

Imiquimod(Synonyms: 咪喹莫特; R 837)

Imiquimod Chemical Structure

CAS No. : 99011-02-6

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200 mg ￥710 In-stock
500 mg ￥1500 In-stock
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生物活性

Imiquimod (R 837), an immune response modifier, is a selective toll like receptor 7 (TLR7) agonist. Imiquimod exhibits antiviral and antitumor effects in vivo. Imiquimod can be used for the research of external genital, perianal warts, cancer and COVID-19[1][2].

IC50 & Target[1][3]

TLR7

 

HSV-1

 

体内研究
(In Vivo)

In animal models, Imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

240.30

Formula

C14H16N4
CAS 号

99011-02-6
中文名称

咪喹莫特
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 2.64 mg/mL (10.99 mM; ultrasonic and adjust pH to 2 with HCl)

DMSO : 2 mg/mL (8.32 mM; ultrasonic and warming and heat to 70°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.1615 mL 20.8073 mL 41.6146 mL
5 mM 0.8323 mL 4.1615 mL 8.3229 mL
10 mM 0.4161 mL 2.0807 mL 4.1615 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Athina Angelopoulou, et al. Imiquimod – A toll like receptor 7 agonist – Is an ideal option for management of COVID 19. Environ Res. 2020 Sep; 188: 109858.

    [2]. Aditya K Gupta, et al. Imiquimod: a review. J Cutan Med Surg. Nov-Dec 2002;6(6):554-60.

    [3]. Yuji Kan, et al. Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 2012 Oct;86(19):10338-46.

    [4]. Michael P Schön, et al. The small antitumoral immune response modifier imiquimod interacts with adenosine receptor signaling in a TLR7- and TLR8-independent fashion. J Invest Dermatol. 2006 Jun;126(6):1338-47.

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