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D-Lin-MC3-DMA 纯度: ≥98.0%
D-Lin-MC3-DMA 是一种可电离的阳离子脂质, 是一种有效的递送 siRNA 载体。
D-Lin-MC3-DMA Chemical Structure
CAS No. : 1224606-06-7
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥1808 | In-stock | |
5 mg | ¥1280 | In-stock | |
10 mg | ¥1850 | In-stock | |
25 mg | ¥3700 | In-stock | |
50 mg | ¥5500 | In-stock | |
100 mg | ¥8500 | In-stock | |
200 mg | 询价 | ||
500 mg | 询价 |
* Please select Quantity before adding items.
D-Lin-MC3-DMA 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Anti-Cancer Compound Library
生物活性 |
D-Lin-MC3-DMA, an ionizable cationic lipid, is a potent siRNA delivery vehicle. |
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体内研究 (In Vivo) |
Lipid nanoparticles (LNPs) containing distearoylphosphatidlycholine (DSPC), and ionizableamino-lipids such as dilinoleylmethyl-4-dimethylaminobutyrate (DLin-MC3-DMA) are potent siRNA delivery vehicles in vivo. LNP-siRNA systems optimize to achieve maximum gene silencing potency in hepatocytesfollowing IV administration in mice contain DLin-MC3-DMA (MC3), DSPC, cholesterol and a polyethyleneglycol (PEG)-lipid at mole ratios of 50/10/38.5/1.5. DLin-MC3-DMA exhibits an optimized pKa value that leads to dramatically enhanced potency[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
642.09 |
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Formula |
C43H79NO2 |
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CAS 号 |
1224606-06-7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (155.74 mM; Need ultrasonic) Ethanol : 100 mg/mL (155.74 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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