Hydroxyflutamide(Synonyms: HFT)

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Hydroxyflutamide (Synonyms: HFT)

Hydroxyflutamide (HF)，Flutamide 的活性代谢物，是一种有效的雄激素受体 (androgen receptor) 拮抗剂 (IC50=700 nM)。Hydroxyflutamide 可用于前列腺癌的研究。

Hydroxyflutamide(Synonyms: HFT)

Hydroxyflutamide Chemical Structure

CAS No. : 52806-53-8

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生物活性

Hydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). Hydroxyflutamide can be used for the research of prostate cancer[1][2].

IC50 & Target

IC50: 700 nM (androgen receptor)[1]
分子量

292.21

Formula

C11H11F3N2O4
CAS 号

52806-53-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Furr BJ, et, al. Casodex: preclinical studies and controversies. Ann N Y Acad Sci. 1995 Jun 12;761:79-96.

    [2]. Liu HL, et, al. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations. Int J Mol Sci. 2017 Aug 23;18(9):1823.

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