TMX-4116

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

TMX-4116 

TMX-4116 是酪蛋白激酶 1α (CK1α) 降解剂。TMX-4116 在 MOLT4、Jurkat 和 MM.1S 细胞中显示出对 CK1α 的降解偏好，DC50 小于 200 nM。TMX-4116 可用于多发性骨髓瘤的研究。

TMX-4116

TMX-4116 Chemical Structure

规格 价格 是否有货
5 mg ￥4800 询问价格 & 货期
10 mg ￥8000 询问价格 & 货期

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生物活性

TMX-4116 is a casein kinase 1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma[1].

IC50 & Target[1]

CK1α

 

体外研究
(In Vitro)

TMX-4116 (compound 16; 1 μM; 4 h) shows a high degradation preference for CK1α in MOLT4 cells[1].
TMX-4116 (250 nM, 4 h) induces primary target degradation of CK1α, while no downregulation of PDE6D, IKZF1, and IKZF3 in MOLT4 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MOLT4 cells
Concentration: 1 μM
Incubation Time: 4 hours
Result: Showed a high degradation preference for CK1α.

Western Blot Analysis[1]

Cell Line: MOLT4, Jurkat, and MM.1S cells
Concentration: 0 nM, 40 nM, 200 nM, 1 μM
Incubation Time: 4 hours
Result: Showed a high degradation preference for CK1α with the DC50 value less than 200 nM in MOLT4, Jurkat, and MM.1S cells.

分子量

389.43

Formula

C17H19N5O4S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Teng M, et al. Development of PDE6D and CK1α Degraders through Chemical Derivatization of FPFT-2216. J Med Chem. 2022 Jan 13;65(1):747-756.

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