FLT3-IN-4 | whatman (沃特曼)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

FLT3-IN-4

FLT3-IN-4 是一种口服有效的 Fms 样酪氨酸受体激酶 3 (FLT3; IC₅₀= 7 nM) 抑制剂，可用于急性髓性白血病的研究。

FLT3-IN-4 Chemical Structure

CAS No. : 2304799-09-3

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生物活性	FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC₅₀=7 nM) inhibitor for treating acute myelogenous leukemia^[1].
体外研究 (In Vitro)	FLT3-IN-4 (Compound 9u) shows potent inhibitory activities against MV4-11 and Molm-13 cells with IC₅₀ values are 0.089±0.001 nM and 0.022±0.003 nM, respectively^[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	431.49
Formula	C₂₃H₂₅N₇O₂
CAS 号	2304799-09-3
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Yuan X, et al. Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia. J Med Chem. 2019 Apr 25;62(8):4158-4173.

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