Pomalidomide-PEG6-butyl iodide

发表于由

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Pomalidomide-PEG6-butyl iodide 

Pomalidomide-PEG6-butyl iodide 是一种合成的 E3 ligase ligand-linker conjugate，包含基于 Pomalidomide 的 cereblon 配体和 6 个单元 PEG 的 linker。

Pomalidomide-PEG6-butyl iodide

Pomalidomide-PEG6-butyl iodide Chemical Structure

CAS No. : 1835705-74-2

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生物活性

Pomalidomide-PEG6-butyl iodide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 6-unit PEG linker used in PROTAC technology[1].

IC50 & Target

Cereblon

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

761.60

Formula

C31H44IN3O11
CAS 号

1835705-74-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lai AC, et al. Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL. Angew Chem Int Ed Engl. 2016 Jan 11;55(2):807-10.

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