上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。
Saridegib (Synonyms: IPI-926; Patidegib) 纯度: ≥99.0%
Saridegib 是 Smo 的特异性有效抑制剂，这是 Hedgehog 通路中关键的跨膜信号蛋白。
Saridegib Chemical Structure
CAS No. : 1037210-93-7
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 5 mg | ￥23800 | 询问价格 & 货期 | |
* Please select Quantity before adding items.
| 生物活性 |
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway. |
IC50 & Target |
Smo[1]. |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 体内研究 (In Vivo) |
Evidence from a genetically engineered mouse model of pancreatic cancer demonstrates that Saridegib (IPI-926) can deplete tumor-associated stromal tissue and increase intratumoral mean vessel density. These changes result in enhanced delivery of concurrently administered systemic agents, leading to a decreased tumor burden and prolonged survival in this mouse model[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
| Clinical Trial |
|
||||||||||||
| 分子量 |
504.77 |
||||||||||||
| Formula |
C29H48N2O3S |
||||||||||||
| CAS 号 |
1037210-93-7 |
||||||||||||
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||
| 储存方式 |
|
||||||||||||
| 参考文献 |
|
所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务