Z-Ile-Leu-aldehyde(Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)

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Z-Ile-Leu-aldehyde (Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII) 纯度: ≥98.0%

Z-Ile-Leu-aldehyde (Z-IL-CHO) 是有效的、竞争性的 γ-secretase 和 notch 的肽醛抑制剂。

Z-Ile-Leu-aldehyde(Synonyms: Z-IL-CHO; GSI-XII; γ-Secretase inhibitor XII)

Z-Ile-Leu-aldehyde Chemical Structure

CAS No. : 161710-10-7

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2791 In-stock
2 mg ￥2333 In-stock
5 mg ￥3500 In-stock
10 mg ￥5000 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

Z-Ile-Leu-aldehyde (Z-IL-CHO) is a potent and competitive peptide aldehyde inhibitor of γ-secretase and notch[1][2].

体外研究
(In Vitro)

Z-Ile-Leu-aldehyde (ILCHO) significantly downregulates Th17-associated cytokine levels in murine Th17 in vitro polarization assays[1].
Z-Ile-Leu-aldehyde (GSI XII) induces apoptosis of murine MOPC315.BM myeloma cells with high Notch activity[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCRsup>[1]

Cell Line: CD4+ T cells from C57BL/6 mice.
Concentration: 25 μM.
Incubation Time: 24, 48, 72 hours.
Result: DownregulateD RORt and IL-17 mRNA expression.

Cell Viability Assaysup>[2]

Cell Line: MOPC315.BM cells.
Concentration: 0, 12, 15 μM.
Incubation Time: 24-48 h hours.
Result: Reduced viability and induced apoptosis in MOPC315.BM cells

体内研究
(In Vivo)

Z-Ile-Leu-aldehyde (GSI XII, 10 mg/kg, Intraperitoneally either for 14 days) controls myeloma bone disease mainly by targeting Notch in MM cells and possibly in osteoclasts in their microenvironment[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MOPC315.BM mouse model[2].
Dosage: 10 mg/kg.
Administration: Intraperitoneally either for 14 days.
Result: Reduces myeloma-specific paraprotein levels in the MOPC315.BM model.
Diminished osteolytic lesions in the MOPC315.BM mice.

分子量

362.46

Formula

C20H30N2O4
CAS 号

161710-10-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 41 mg/mL (113.12 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7589 mL 13.7946 mL 27.5893 mL
5 mM 0.5518 mL 2.7589 mL 5.5179 mL
10 mM 0.2759 mL 1.3795 mL 2.7589 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Reem Suleiman, et al. The Role Of Notch In Th17 Differentiation. University of Massachusetts Amherst. 9-2013.

    [2]. Schwarzer R, et al. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model. Blood Cancer J. 2014 Jun 13;4:e217.

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