上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
Pentachloropseudilin (Synonyms: Antibiotic A 15104 Y; PClP)
Pentachloropseudilin (Antibiotic A 15104 Y; PClP) 是一种可逆的、变构有效的肌球蛋白 (Myo1s) 抑制剂,对 Myo1s 的 IC50 范围为 1 至 5 μM,对于 2 类和 5 类肌球蛋白,IC50 范围 > 90 μM。Pentachloropseudilin 是转化生长因子-β (TGF-β) 刺激的信号传导的有效抑制剂,对 TGF-β 的 IC50 值为 0.1-0.2 μM。
Pentachloropseudilin Chemical Structure
CAS No. : 69640-38-6
规格 | 价格 | 是否有货 | |
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5 mg | ¥9800 | 询问价格 & 货期 |
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生物活性 |
Pentachloropseudilin (Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC50s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β (TGF-β)-stimulated signaling, with an IC50 of 0.1 to 0.2 μM for TGF-β[1][2]. |
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体外研究 (In Vitro) |
Pentachloropseudilin (PClP) inhibits TGF-β-stimulated Smad2/3 phosphorylation and plasminogen activator inhibitor-1 (PAI-1) promoter activation with an IC50 of 0.1 μM in target cells (A549, HepG2, and Mv1Lu cells)[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
331.41 |
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Formula |
C10H4Cl5NO |
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CAS 号 |
69640-38-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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参考文献 |
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