上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
SPI-112 纯度: 97.06%
SPI-112 是一种有效的,选择性和竞争性的 SHP2 (PTPN11) 抑制剂,对 SHP2,蛋白酪氨酸磷酸酶 (PTP) 和 PTP1B 的 IC50 分别为 1 μM,18.3 μM 和 14.5 μM。
SPI-112 Chemical Structure
CAS No. : 1051387-90-6
规格 | 价格 | 是否有货 | 数量 |
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10 mM * 1 mL in DMSO | ¥550 | In-stock | |
10 mg | ¥500 | In-stock | |
25 mg | ¥1000 | In-stock | |
50 mg | ¥1800 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
* Please select Quantity before adding items.
SPI-112 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
- Metabolism/Protease Compound Library
- Anti-Cancer Compound Library
- Phosphatase Inhibitor Library
- Anti-Obesity Compound Library
生物活性 |
SPI-112 is a potent, selective and competitive SHP2 (PTPN11) inhibitor with IC50s of 1 μM, 18.3 μM and 14.5 μM for SHP2, protein tyrosine phosphatase (PTP) and PTP1B, respectively[1][2]. |
IC50 & Target |
IC50: 1 μM (SHP2), 18.3 μM (PTP) and 14.5 μM (PTP1B)[2] |
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体外研究 (In Vitro) |
SPI-112 has a polar -NO2 or a negatively charged -COOH group and has no detectable cellular activity, suggesting that SPI-112 is not cell permeable[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
468.46 |
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Formula |
C22H17FN4O5S |
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CAS 号 |
1051387-90-6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
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溶解性数据 |
In Vitro:
DMSO : 50 mg/mL (106.73 mM; Need ultrasonic) 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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