N-(5-Hydroxypentyl)maleimide

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N-(5-Hydroxypentyl)maleimide  纯度: 99.66%

N-(5-Hydroxypentyl)maleimide 是一种不可降解 (non-cleavable) 的 ADC linker，可用于合成抗体偶联药物 (ADC)，例如 Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812)。

N-(5-Hydroxypentyl)maleimide

N-(5-Hydroxypentyl)maleimide Chemical Structure

CAS No. : 180608-78-0

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生物活性

N-(5-Hydroxypentyl)maleimide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as Gemcitabine-O-Si(di-iso)-O-Mc (HY-130812) )[1].

IC50 & Target[1]

Non-cleavable

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker)[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

183.20

Formula

C9H13NO3
CAS 号

180608-78-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
参考文献

  • [1]. Finniss, M. C., et al. A versatile acid-labile linker for antibody–drug conjugates. Med. Chem. Commun., 2014, 5(9), 1355-1358.

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