Groenlandicine(Synonyms: 格兰地新)

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Groenlandicine (Synonyms: 格兰地新) 纯度: 99.69%

Groenlandicine 是从黄连中分离得到的一种原小檗碱生物碱。Groenlandicine 对人类重组醛糖还原酶 (HRAR) 具有中度的抑制作用，IC50 值为 154.2 μM。Groenlandicine 能诱导拓扑异构酶 I (topoisomerase I) 介导的 DNA 裂解。

Groenlandicine(Synonyms: 格兰地新)

Groenlandicine Chemical Structure

CAS No. : 38691-95-1

规格 价格 是否有货 数量
1 mg ￥1900 In-stock
5 mg ￥5710 In-stock
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生物活性

Groenlandicine is a protoberberine alkaloid isolated from Coptidis Rhizoma. Groenlandicine exhibits moderate inhibitory effect with IC50 value of 154.2 μM for human recombinant aldose reductase (HRAR)[1]. Groenlandicine selectively induces topoisomerase I-mediated DNA cleavage[2].

IC50 & Target

Topoisomerase I

 

分子量

322.33

Formula

C19H16NO4+
CAS 号

38691-95-1
中文名称

格兰地新
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献

  • [1]. Jung HA, et al. Inhibitory activities of the alkaloids from Coptidis Rhizoma against aldose reductase. Arch Pharm Res. 2008 Nov;31(11):1405-12.

    [2]. Kobayashi Y, et al. Inhibitors of DNA topoisomerase I and II isolated from the Coptis rhizomes. Planta Med. 1995 Oct;61(5):414-8.

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