Manumycin A(Synonyms: 手霉素A)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Manumycin A (Synonyms: 手霉素A) 纯度: ≥98.0%

Manumycin A 是一种抗生素。Manumycin A 作为一种选择性、竞争性的 farnesyltransferase (FTase) 抑制剂，与 farnesylpyrophosphate (Ki =1.2 μM) 有关，并且作为 Ras 蛋白质的非竞争性抑制剂。Manumycin A 诱导细胞凋亡并发挥抗肿瘤活性。Manumycin A 通过靶向抑制 Ras/Raf/ERK1/2 信号转导，抑制外泌体生物发生 (exosome biogenesis) 及分泌。Manumycin A 也是 nSMase 抑制剂 (EC50=0.25 μM)。

Manumycin A(Synonyms: 手霉素A)

Manumycin A Chemical Structure

CAS No. : 52665-74-4

规格 价格 是否有货
1 mg ￥3200 询问价格 & 货期
5 mg ￥10500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Manumycin A is an antibiotic. Manumycin A acts as a selective, competitive inhibitor of protein farnesyltransferase (FTase) with respect to farnesylpyrophosphate (Ki =1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein. Manumycin A induces apoptosis and exerts antitumor activity[1] [2][3]. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling[4]. Manumycin A is a nSMase inhibitor (EC50=0.25 μM)[5].

IC50 & Target

Farnesyltransferase, Ras, nSMase inhibitor[1][5]
分子量

550.64

Formula

C31H38N2O7
CAS 号

52665-74-4
中文名称

手霉素A
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Hara M, et al. Identification of Ras farnesyltransferase inhibitors by microbial screening. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2281-5.

    [2]. Bernier M, et al. Binding of manumycin A inhibits IkappaB kinase beta activity. J Biol Chem. 2006 Feb 3;281(5):2551-61.

    [3]. Kim KH, et al. Manumycin A induces apoptosis in malignant pleural mesothelioma through regulation of Sp1 and activation of the mitochondria-related apoptotic pathway. Oncol Rep. 2016 Jul;36(1):117-24.

    [4]. Datta, A. et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in Castration resistant prostate cancer cells. Cancer Let. 408, 73–81 (2017).

    [5]. Zhang H, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020;35(1):1322-1330.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务