Levomefolate calcium(Synonyms: 左旋甲状腺素钙)

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Levomefolate calcium (Synonyms: 左旋甲状腺素钙) 纯度: 97.11%

Levomefolate calcium 是叶酸的人造形式，抗叶酸的作用。

Levomefolate calcium(Synonyms: 左旋甲状腺素钙)

Levomefolate calcium Chemical Structure

CAS No. : 151533-22-1

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生物活性

Levomefolate calcium is an artificial form of folate. IC50 Value: Target: Antifolate The calcium salt of L-5-methyltetrahydrofolic acid which belongs to the group of folate vitamins (Vitamin B9, Folacin). It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements.

Clinical Trial

分子量

497.52

Formula

C20H23CaN7O6
CAS 号

151533-22-1
中文名称

左旋甲状腺素钙
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

H2O : 4.4 mg/mL (8.84 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0100 mL 10.0498 mL 20.0997 mL
5 mM 0.4020 mL 2.0100 mL 4.0199 mL
10 mM — — —

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Fruzzetti F. Beyaz?: an oral contraceptive fortified with folate. Womens Health (Lond Engl). 2012 Jan;8(1):13-9.

    [2]. Wiesinger H, Eydeler U, Richard F, et al. Bioequivalence evaluation of a folate-supplemented oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium versus ethinylestradiol/drospirenone and levomefolate calcium alone. Clin Drug Investig. 2012 Oct 1;32(10):673-84.

    [3]. Hartmut Blodea, Christine Klippingb, Frank Richardc, et al. Bioequivalence study of an oral contraceptive containing ethinylestradiol/drospirenone/levomefolate calcium relative to ethinylestradiol/drospirenone and to levomefolate calcium alone. Contraception.2012, 85(2), :177-184

    [4]. Rapkin RB, Creinin MD. The combined oral contraceptive pill containing drospirenone and ethinyl estradiol plus levomefolate calcium. Expert Opin Pharmacother. 2011 Oct;12(15):2403-10. doi: 10.1517/14656566.2011.610791.

    [5]. Levomefolic_acid

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