上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
MS31
MS31 是一种高亲和性,高选择性,片段样的甲基赖氨酸读写蛋白 spindlin 1 (SPIN1) 抑制剂,有效破坏 SPIN1 与 H3K4me3 蛋白互相作用 (IC50=77 nM,AlphaLISA;243 nM,FP). MS31 选择性结合 SPIN1 的 Tudor 结构域 II (Kd=91 nM)。MS31 能有效抑制含三甲基赖氨酸肽与 SPIN1 的结合,对非肿瘤性细胞无毒。
MS31 Chemical Structure
CAS No. : 2366264-12-0
规格 | 价格 | 是否有货 | |
---|---|---|---|
5 mg | ¥4500 | 询问价格 & 货期 | |
10 mg | ¥6500 | 询问价格 & 货期 | |
50 mg | ¥16500 | 询问价格 & 货期 | |
100 mg | ¥22500 | 询问价格 & 货期 |
* Please select Quantity before adding items.
MS31 的其他形式现货产品:
生物活性 |
MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells[1]. |
IC50 & Target |
IC50: 77 nM (SPIN1 by AlphaLISA), 243 nM (SPIN1 by FP)[1] |
---|---|
体外研究 (In Vitro) |
MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1, displays high binding affinity, is highly selective for SPIN1 over other epigenetic readers and writers, directly engages SPIN1 in cells, and is not toxic to nontumorigenic cells. MS31 selectively binds tudor domain II of SPIN1[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
341.45 |
Formula |
C20H27N3O2 |
CAS 号 |
2366264-12-0 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务