MCT1-IN-2

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

MCT1-IN-2  纯度: ≥99.0%

MCT1-IN-2 是有效的单羧酸盐转运蛋白 1 (MCT1) 抑制剂。MCT1-IN-2 具有抗癌活性。

MCT1-IN-2

MCT1-IN-2 Chemical Structure

CAS No. : 227321-12-2

规格 价格 是否有货 数量
1 mg ￥2800 In-stock
5 mg ￥8900 询价
10 mg   询价  
50 mg   询价  

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生物活性

MCT1-IN-2 is a potent monocarboxylate transporter 1 (MCT1) inhibitor. MCT1-IN-2 has anti-cancer activity[1][2].

体外研究
(In Vitro)

MCT1-IN-2 (compound 3) has a pKi of 9.48 for Jurkat T-cells and inhibits human peripheral blood mononuclear cells (PBMC) proliferation (pIC50=8.61)[1].
MCT1-IN-2 (compound 1) has an EC50 of 5.5 nM (MTT assay) and an IC50 of 105 nM (lactate transport inhibition assay) in human Raji lymphoma cell proliferation[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

435.58

Formula

C25H29N3O2S
CAS 号

227321-12-2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Clare M Murray, et al. Monocarboxylate transporter MCT1 is a target for immunosuppression. Nat Chem Biol. 2005 Dec;1(7):371-6.

    [2]. Hui Wang, et al. Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. J Med Chem. 2014 Sep 11;57(17):7317-24.

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