Ro24-7429

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Ro24-7429 

Ro24-7429 是一种有效且具有口服活性的 HIV-1 反式激活蛋白 Tat 拮抗剂。Ro24-7429 也是 RUNX1 抑制剂。Ro24-7429 具有抗 HIV、抗纤维化和抗炎作用。

Ro24-7429

Ro24-7429 Chemical Structure

CAS No. : 139339-45-0

规格 价格 是否有货
5 mg ￥2500 询问价格 & 货期
10 mg ￥3800 询问价格 & 货期
25 mg ￥7500 询问价格 & 货期
50 mg ￥12000 询问价格 & 货期
100 mg ￥18000 询问价格 & 货期

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生物活性

Ro24-7429 is a potent and orally active HIV-1 transactivator protein Tat antagonist. Ro24-7429 is also a runt-related transcription factor 1 (RUNX1) inhibitor. Ro24-7429 has anti-HIV, antifibrotic and anti-inflammatory effects[1][2].

体外研究
(In Vitro)

Ro 24-7429 (0.1-5 μM; 3 days) induces apoptosis of cultured PBMCs in a dose-dependent manner[1].
Ro 24-7429 (1-25 μM) also induces apoptosis and inhibits antigen-induced lymphocyte proliferation[1].
Ro24-7429 (50-200 μM; 24-72 hours) strongly inhibits the proliferation of A549 and HLF cells in a dose-dependent manner. Ro24-7429 treatment (75 μM) significantly reduces TNF-α-induced up-regulation of RUNX1 mRNA by 50% at 48 hours[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: Peripheral blood mononuclear cells (PBMCs)
Concentration: 0.1 μM, 1 μM, 5 μM
Incubation Time: 3 days
Result: Induced a dose-dependent increase in apoptosis of cultured PBMCs.

体内研究
(In Vivo)

Ro24-7429 (17.5-70 mg/kg; i.p.; daily; for 14 or 21 days) treatment robustly ameliorates lung fibrosis and inflammation in the Bleomycin-induced pulmonary fibrosis (PF) mouse model. Ro24-7429 curbs expression of fibrosis markers in injured mouse lungs[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J male and female mice (aged 6 to 8 weeks) induced by Bleomycin[2]
Dosage: 17.5 mg/kg, 35 mg/kg, and 70 mg/kg
Administration: i.p.; daily; for 14 or 21 days
Result: Ameliorated lung fibrosis and inflammation in the Bleomycin-induced PF mouse model.

Clinical Trial

分子量

272.73

Formula

C14H13ClN4
CAS 号

139339-45-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. A H Patki, et al. HIV-1 Tat protein and its inhibitor Ro 24-7429 inhibit lymphocyte proliferation and induce apoptosis in peripheral blood mononuclear cells from healthy donors. Cell Immunol. 1996 Apr 10;169(1):40-6.

    [2]. Michael O’Hare, et al. Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 Jul;191(7):1193-1208.

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