Isosilybin B(Synonyms: 异水飞蓟宾B)

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Isosilybin B (Synonyms: 异水飞蓟宾B)

Isosilybin B,一种从 silymarin 中分离的黄酮木脂素,具有抗前列腺癌 (PCA) 活性,抑制癌细胞增殖,诱导 G1 期阻滞和凋亡。Isosilybin B 引起雄激素受体降解。

Isosilybin B(Synonyms: 异水飞蓟宾B)

Isosilybin B Chemical Structure

CAS No. : 142796-22-3

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生物活性

Isosilybin B, a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation[1][2].

分子量

482.44

Formula

C25H22O10

CAS 号

142796-22-3

中文名称

异水飞蓟宾B

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献
  • [1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.

    [2]. Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27(28):3986-98.

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