Hirsutine(Synonyms: 毛钩藤碱)

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Hirsutine (Synonyms: 毛钩藤碱) 纯度: ≥99.0%

Hirsutine，一种 Uncaria rhynchophylla 的吲哚生物碱，具有抗癌活性。Hirsutine 诱导细胞凋亡，并且是一种有效的 Dengue virus 抑制剂，具有低毒性。

Hirsutine(Synonyms: 毛钩藤碱)

Hirsutine Chemical Structure

CAS No. : 7729-23-9

规格 价格 是否有货 数量
1 mg ￥3810 In-stock
5 mg ￥11430 In-stock
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Hirsutine 相关产品

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生物活性

Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity[1][2][3].

体外研究
(In Vitro)

Hirsutine remarkably reduces the viability of MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner with IC50 values of 447.79 and 179.06 μM, respectively. In the MDA-MB-231 cells, Hirsutine induces apoptosis and depolarization of MMP, releases Cyt C from mitochondria, and activates caspase 9 and caspase 3[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells[3].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

368.47

Formula

C22H28N2O3
CAS 号

7729-23-9
中文名称

毛钩藤碱； 毛帽柱木碱； 二氢柯楠因碱； 陆地棉苷
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Hishiki T, et al. Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle. Front Microbiol. 2017 Aug 30;8:1674.

    [2]. Huang QW, et al. [Hirsutine induces apoptosis of human breast cancer MDA-MB-231 cells through mitochondrial pathway]. Sheng Li Xue Bao. 2018 Feb 25;70(1):40-46.

    [3]. Zhang R, et al. Hirsutine induces mPTP-dependent apoptosis through ROCK1/PTEN/PI3K/GSK3β pathway in human lung cancer cells. Cell Death Dis. 2018 May 22;9(6):598.

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