GW7604

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

GW7604  纯度: ≥98.0%

GW7604 是一种抗雌激素药。GW7604 是 GW5638 的代谢物。GW5638 是一种高亲和力的雌激素受体 (ER) 拮抗剂。

GW7604

GW7604 Chemical Structure

CAS No. : 195611-82-6

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5 mg ￥5500 询问价格 & 货期

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GW7604 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Anti-Cancer Compound Library
  • Anti-Breast Cancer Compound Library

生物活性

GW7604 is an antiestrogen. GW7604 is the metabolite of GW5638, which is a high affinity estrogen receptor (ER) antagonist[1].

体外研究
(In Vitro)

GW7604 is the presumed metabolite of GW5638 in breast (MCF-7) and endometrial (ECC-1) cell lines. GW7604 (0.1 nM-1 μM; 24 hours) inhibits both Estradiol (1 nM) and 4-hydroxytamoxifen (4-OHT; 10 and 100 nM) induction of TGF-alpha in a concentration related manner (1-1000 nM) in MDA-MB-231 cells[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: MDA-MB-231 cells
Concentration: 0.1 nM, 1 nM, 10 nM, 100 nM, 1 μM
Incubation Time: 24 hours
Result: Blocked the effect of estradiol (E2; 1 n M) in a concentration-related manner.

分子量

370.44

Formula

C25H22O3
CAS 号

195611-82-6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Bentrem D, et al. Molecular mechanism of action at estrogen receptor alpha of a new clinically relevant antiestrogen (GW7604) related to tamoxifen. Endocrinology. 2001 Feb;142(2):838-46.

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