NU2058(Synonyms: O6-(Cyclohexylmethyl)guanine)

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NU2058 (Synonyms: O6-(Cyclohexylmethyl)guanine) 纯度: 98.78%

NU2058 (O6-(Cyclohexylmethyl)guanine) 是一种 CDK 抑制剂, 抑制 CDK2 和 CDK1 的 IC50 值分别为 17 μM 和 26 μM。NU2058 具有抗癌活性。

NU2058(Synonyms: O6-(Cyclohexylmethyl)guanine)

NU2058 Chemical Structure

CAS No. : 161058-83-9

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥620 In-stock
5 mg ￥550 In-stock
10 mg ￥960 In-stock
50 mg ￥2560 In-stock
100 mg ￥4000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

NU2058 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Kinase Inhibitor Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Nucleotide Compound Library
  • Anti-Breast Cancer Compound Library
  • Anti-Blood Cancer Compound Library

生物活性

NU2058 (O6-(Cyclohexylmethyl)guanine) is a potent, competitive and guanine-based CDK inhibitor with IC50s of 17 μM and 26 μM for CDK2 and CDK1. NU2058 has anti-cancer activity.

IC50 & Target[1]

CDK1

26 μM (IC50)

CDK2

17 μM (IC50)

CDK2

12 μM (Ki)

体外研究
(In Vitro)

NU2058 (O6-(Cyclohexylmethyl)guanine) is a competitive inhibitor of CDK2 with respect to ATP (Ki value CDK2, 12 μM) that binds in the ATP binding pocket in a different orientation from other purine-based inhibitors, including olomoucine and roscovotine. NU2058 is the lead compound in a structure-based drug discovery program to develop more potent and selective CDK inhibitors.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

247.30

Formula

C12H17N5O
CAS 号

161058-83-9
中文名称

O6-环甲基己基鸟嘌呤
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 32 mg/mL (129.40 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0437 mL 20.2184 mL 40.4367 mL
5 mM 0.8087 mL 4.0437 mL 8.0873 mL
10 mM 0.4044 mL 2.0218 mL 4.0437 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Rigas AC, et al. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer. Oncogene. 2007 Dec 6;26(55):7611-7619.

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