上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白,专注于信号通路和疾病研究领域。
CDK12-IN-2 纯度: 99.44%
CDK12-IN-2是一种高效、选择性的纳摩尔级别的CDK12 抑制剂 (IC50=52 nM),具有良好的物理化学性质。CDK12-IN-2也是一种强的CDK13抑制剂,因为CDK13是CDK12最接近的同源物。CDK12-IN-2对CDK12的激酶选择性比CDK2、9、8和7高。CDK12-IN-2抑制RNA polymerase II 的 C端Ser2磷酸化。CDK12-IN-2可以作为一种很好的化学探针用于CDK12的功能研究。
CDK12-IN-2 Chemical Structure
CAS No. : 2244987-03-7
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5 mg | ¥3500 | In-stock | |
10 mg | ¥6000 | In-stock | |
25 mg | ¥11500 | In-stock | |
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CDK12-IN-2 相关产品
•相关化合物库:
- Bioactive Compound Library Plus
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- Anti-Cancer Compound Library
- Anti-Aging Compound Library
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- Anti-Blood Cancer Compound Library
生物活性 |
CDK12-IN-2 is a potent, selective and nanomolar CDK12 inhibitor (IC50=52 nM) with good physicochemical properties. CDK12-IN-2 is also a strong CDK13 inhibitor due to CDK13 is the closest homologue of CDK12. CDK12-IN-2 shows excellent kinase selectivity for CDK12 over CDK2, 9, 8, and 7. CDK12-IN-2 inhibits the phosphorylation of Ser2 in the C-terminal domain of RNA polymerase II. CDK12-IN-2 can be used an excellent chemical probe for functional studies of CDK12[1]. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
CDK12-IN-2 inhibits the phosphorylation of the CTD Ser2 in SK-BR-3 cells at low submicromolar concentrations, it inhibits C-terminal domain ser2 phosphorylation with an IC50 of 185 nM. And CDK12-IN-2 exhibits a growth inhibition with an IC50 of 0.8 μM in SK-BR-3 cells[1].CDK12-IN-2 exhibits time dependency for CDK12 inhibition, the IC50 value for CDK12-IN-2 are 0.0078 μM, 0.042 μM, 0.057 μM,and 0.059 μM, for 0h, 1h, 2h and 5h respectively[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
532.64 |
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Formula |
C32H32N6O2 |
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CAS 号 |
2244987-03-7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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参考文献 |
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