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Niraparib (R-enantiomer) (Synonyms: MK 4827 (R-enantiomer)) 纯度: 99.50%
Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种高效的 PARP1 抑制剂,IC50 为 2.4 nM。
![Niraparib (R-enantiomer) Chemical Structure Niraparib (R-enantiomer)(Synonyms: MK 4827 (R-enantiomer))](http://www.fluoroprobe.com/wp-content/uploads/2022/05/hy-10619d.gif)
Niraparib (R-enantiomer) Chemical Structure
CAS No. : 1038915-58-0
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | Apply now | ||
10 mM * 1 mL in DMSO | ¥2115 | In-stock | |
2 mg | ¥1200 | In-stock | |
5 mg | ¥2200 | In-stock | |
10 mg | ¥3800 | In-stock | |
50 mg | ¥9900 | In-stock | |
100 mg | 询价 | ||
200 mg | 询价 |
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Niraparib (R-enantiomer) 相关产品
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生物活性 |
Niraparib R-enantiomer (MK-4827 R-enantiomer) is an excellent PARP1 inhibitor with IC50 of 2.4 nM. |
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IC50 & Target[1] |
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体外研究 (In Vitro) |
Niraparib R-enantiomer (MK-4827 R-enantiomer) resolution of Niraparib R-enantiomer give compounds Niraparib R-enantiomer and Niraparib S-enantiomer, both showing excellent inhibition of PARP-1. Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). Given this improved potency and similar in vitro turnover in human liver microsomes (HLM Clint, Niraparib R-enantiomer=4, Niraparib S-enantiomer=3 μL/min/mgP), Niraparib S-enantiomer (Niraparib) is focused on[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
320.39 |
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Formula |
C19H20N4O |
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CAS 号 |
1038915-58-0 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:
DMSO : ≥ 32 mg/mL (99.88 mM) * “≥” means soluble, but saturation unknown. 配制储备液
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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