Tos-O-C4-NH-Boc

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

Tos-O-C4-NH-Boc  纯度: 96.31%

Tos-O-C4-NH-Boc 是一种 PROTAC linker，属于 alkyl ether 类。Boc-NH-C6-amido-C4-acid 可用于合成 PROTAC 分子，例如 BSJ-03-204 (HY-136250)。

Tos-O-C4-NH-Boc

Tos-O-C4-NH-Boc Chemical Structure

CAS No. : 180851-50-7

规格 价格 是否有货 数量
500 mg ￥500 In-stock
1 g   询价  
5 g   询价  

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生物活性

Tos-O-C4-NH-Boc is an alkyl ether-based PROTAC linker can be used in the synthesis of PROTACs, such as BSJ-03-204 (HY-136250)[1].

IC50 & Target[1]

Alkyl/ether

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

343.44

Formula

C16H25NO5S
CAS 号

180851-50-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Targ. J Med Chem. 2019 Aug 21.

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