Amino-PEG3-C2-acid

发表于由

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Amino-PEG3-C2-acid 

Amino-PEG3-C2-acid 是一种可降解 (cleavable) 的 4 单元 PEG 类的 ADC linker，用于抗体偶联药物 (ADC) 的合成。Amino-PEG3-C2-acid 是基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。

Amino-PEG3-C2-acid

Amino-PEG3-C2-acid Chemical Structure

CAS No. : 784105-33-5

规格 价格 是否有货 数量
250 mg ￥1000 In-stock
500 mg ￥1500 In-stock
1 g   询价  
5 g   询价  

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生物活性

Amino-PEG3-C2-acid is a cleavable PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG3-C2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Cleavable

 

PEGs

 

体外研究
(In Vitro)

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

221.25

Formula

C9H19NO5
CAS 号

784105-33-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献

  • [1]. Kevin HAMBLETT, et al. Anti-her2 biparatopic antibody-drug conjugates and methods of use. WO2019173911A1.

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