1-Naphthyl PP1 hydrochloride(Synonyms: 1-NA-PP 1 hydrochloride)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

1-Naphthyl PP1 hydrochloride (Synonyms: 1-NA-PP 1 hydrochloride) 纯度: 99.94%

1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) 是一种选择性的 src 家族激酶抑制剂。1-Naphthyl PP1 hydrochloride 抑制 v-Src 和 c-Fyn，c-Abl，CDK2 和CAMK II，IC50 分别为 1.0，0.6，0.6，18 和 22 μM。

1-Naphthyl PP1 hydrochloride(Synonyms: 1-NA-PP 1 hydrochloride)

1-Naphthyl PP1 hydrochloride Chemical Structure

CAS No. : 956025-47-1

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥908 In-stock
5 mg ￥825 In-stock
10 mg ￥1452 In-stock
50 mg ￥5841 In-stock
100 mg ￥9900 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

1-Naphthyl PP1 hydrochloride 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Kinase Inhibitor Library
  • Protein Tyrosine Kinase Compound Library
  • Anti-Cancer Compound Library
  • Reprogramming Compound Library
  • Anti-Pancreatic Cancer Compound Library
  • Angiogenesis Related Compound Library

生物活性

1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively[1].

分子量

353.85

Formula

C19H20ClN5
CAS 号

956025-47-1
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro: 

DMSO : ≥ 73 mg/mL (206.30 mM)

H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8261 mL 14.1303 mL 28.2606 mL
5 mM 0.5652 mL 2.8261 mL 5.6521 mL
10 mM 0.2826 mL 1.4130 mL 2.8261 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Tandon M, et al. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. PLoS One. 2013 Sep 23;8(9):e75601.

    [2]. Bishop AC, et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature. 2000 Sep 21;407(6802):395-401.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务