NLS (PKKKRKV) (hydrochloride)

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NLS (PKKKRKV) (hydrochloride)  纯度: 98.01%

NLS (PKKKRKV) hydrochloride 是一种源于 SV40 大 T 抗原的 NLS，可作为增强核进入方法应用于基因导入。

NLS (PKKKRKV) (hydrochloride)

NLS (PKKKRKV) (hydrochloride) Chemical Structure

规格 价格 是否有货 数量
5 mg ￥900 In-stock
10 mg ￥1500 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

NLS (PKKKRKV) hydrochloride is a nuclear localization signal (NLS) derived from the simian virus 40 large tumor antigen (SV40 large T antigen). NLS (PKKKRKV) can function as a method to enhance nuclear entry in the field of gene transfer research[1][2].

分子量

919.60

Formula

C40H79ClN14O8
Sequence

Pro-Lys-Lys-Lys-Arg-Lys-Val
Sequence Shortening

PKKKRKV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro: 

H2O : 500 mg/mL (543.71 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0874 mL 5.4371 mL 10.8743 mL
5 mM 0.2175 mL 1.0874 mL 2.1749 mL
10 mM 0.1087 mL 0.5437 mL 1.0874 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Zanta MA, et al. Gene delivery: A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):91-6.

    [2]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound-targeted microbubble destruction-mediated gene transfection. Mol Med Rep. 2017 Jul;16(1):565-572.

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