3,4-Dehydro Cilostazol(Synonyms: OPC-13015)

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3,4-Dehydro Cilostazol (Synonyms: OPC-13015) 纯度: 98.01%

3,4-Dehydro Cilostazol (OPC-13015) 是西洛他唑 (Cilostazol; CLZ; HY-17464) 的活性代谢产物。3,4-Dehydro Cilostazol 可用于药代动力学研究。

3,4-Dehydro Cilostazol(Synonyms: OPC-13015)

3,4-Dehydro Cilostazol Chemical Structure

CAS No. : 73963-62-9

规格 价格 是否有货 数量
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1430 In-stock
5 mg ￥1300 In-stock
10 mg ￥2450 In-stock
50 mg ￥5400 In-stock
100 mg ￥9200 In-stock
200 mg   询价  
500 mg   询价  

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3,4-Dehydro Cilostazol 相关产品

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生物活性

3,4-Dehydro Cilostazol (OPC-13015) is an active metabolite of Cilostazol (CLZ; HY-17464). 3,4-Dehydro Cilostazol is used for pharmacokinetic study[1].

体内研究
(In Vivo)

3,4-Dehydro Cilostazol (OPC-13015; Oral; 1 mg/kg GLZ and 10 mg/kg CLZ) has a T1/2 of 3.94 hours, a Cmax of 1.39 μM and an AUC0-24 of 4.69 μg•h/ml. The plasma concentration time profiles of GLZ, CLZ & its active metabolite DCLZ are traceable up to 24 h, 12 h and 12 h respectively by oral administration at 1 mg/kg dose of GLZ and 10 mg/kg CLZ[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 200 g[1]
Dosage: 1 mg/kg Glipizide (GLZ) and 10 mg/kg Cilostazol (CLZ) (Pharmacokinetic Analysis)
Administration: Oral
Result: Had a T1/2 of 3.94 hours, a Cmax of 1.39 μM and an AUC0-24 of 4.69 μg•h/ml.

分子量

367.44

Formula

C20H25N5O2
CAS 号

73963-62-9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 5 mg/mL (13.61 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7215 mL 13.6077 mL 27.2153 mL
5 mM 0.5443 mL 2.7215 mL 5.4431 mL
10 mM 0.2722 mL 1.3608 mL 2.7215 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. T R S Satheeshmanikandan, et al. Liquid Chromatography – Tandem Mass Spectrometry for the Simultaneous Quantitation of Glipizide, Cilostazol and Its Active Metabolite 3, 4-dehydro-cilostazol in Rat Plasma: Application for a Pharmacokinetic Study. Arzneimittelforschung. 2012 Sep;62(9):425-32.

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