I-BET762 carboxylic acid(Synonyms: Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2)

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I-BET762 carboxylic acid (Synonyms: Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2) 纯度: 98.64%

I-BET762 carboxylic acid (Molibresib carboxylic acid) 是基于 I-BET762 的，靶向 BET 的配体。可用于合成 PROTAC 分子。I-BET762 carboxylic acid (Molibresib carboxylic acid) 是一种 BRD4 抑制剂，pIC50 为 5.1。

I-BET762 carboxylic acid(Synonyms: Molibresib carboxylic acid; GSK525762A carboxylic acid; PROTAC BRD4-binding moiety 2)

I-BET762 carboxylic acid Chemical Structure

CAS No. : 1300019-38-8

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2881 In-stock
1 mg ￥1100 In-stock
5 mg ￥3300 In-stock
10 mg ￥5500 In-stock
50 mg ￥16500 In-stock
100 mg   询价  
200 mg   询价  

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I-BET762 carboxylic acid 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Epigenetics Compound Library
  • Histone Modification Research Compound Library
  • Anti-Cancer Compound Library
  • Reprogramming Compound Library
  • Anti-Blood Cancer Compound Library

生物活性

I-BET762 carboxylic acid (Molibresib carboxylic acid) is an I-BET762-based warhead ligand for conjugation reactions of PROTAC targeting on BET. I-BET762 carboxylic acid (Molibresib carboxylic acid) is a BRD4 inhibitor with a pIC50 of 5.1[1].

IC50 & Target

BRD4

5.1 (pIC50)

体外研究
(In Vitro)

I-BET762 carboxylic acid (Molibresib carboxylic acid) (Compound 27) inhibits peripheral blood mononuclear cells (PBMC) with a pIC50 of <4[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

396.83

Formula

C20H17ClN4O3
CAS 号

1300019-38-8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 7.14 mg/mL (17.99 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.5200 mL 12.5999 mL 25.1997 mL
5 mM 0.5040 mL 2.5200 mL 5.0399 mL
10 mM 0.2520 mL 1.2600 mL 2.5200 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Mirguet O, et al. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem. 2013 Oct 10;56(19):7501-15.

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