HB007

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

HB007  纯度: 99.20%

HB007 是一种小的泛素相关修饰剂 1 (SUMO1) 降解剂。HB007 诱导 SUMO1 的泛素化和降解，导致体内肿瘤生长减少。HB007 可用于脑癌、乳腺癌、结肠癌和肺癌的研究。

HB007

HB007 Chemical Structure

CAS No. : 2387821-46-5

规格 价格 是否有货 数量
5 mg ￥3000 In-stock
10 mg ￥4600 In-stock
25 mg ￥9000 In-stock
50 mg ￥13500 In-stock
100 mg   询价  
200 mg   询价  

* Please select Quantity before adding items.

HB007 相关产品

•相关化合物库:

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  • Anti-Liver Cancer Compound Library

生物活性

HB007 is a small ubiquitin-related modifier 1 (SUMO1) degrader. HB007 induces ubiquitination and degradation of SUMO1, resulting in reduced tumor growth in vivo. HB007 can be used for the research of brain, breast, colon, and lung cancers[1][2].

IC50 & Target

SUMO1[1]
体外研究
(In Vitro)

HB007 (compound 24) (0.1-100 μM) inhibits LN229 cell growth in a concentration-dependent manner t[1].
HB007 (10-25 μM) reduces SUM01 conjugation and total protein levels of SUM01 but not SUM02/3 or UB in LN229 cells t[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

HB007 (compound 24) (25-50 mg/kg; i.p. for 15 d) significantly suppresses tumor growth of colon and lung cancer but had no effect on the body weights of mice[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

328.78

Formula

C15H9ClN4OS
CAS 号

2387821-46-5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 31.25 mg/mL (95.05 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.0415 mL 15.2077 mL 30.4155 mL
5 mM 0.6083 mL 3.0415 mL 6.0831 mL
10 mM 0.3042 mL 1.5208 mL 3.0415 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Bellail AC, et, al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors. Sci Transl Med. 2021 Oct 13;13(615):eabh1486.

    [2]. BELLAIL A, et, al. Compositions and methods for treating cancer. WO2019217509A1.

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