PIP-199

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。

PIP-199 

PIP-199 是一种 RecQ 介导的基因组不稳定蛋白 RMI 核心复合物/MM2 相互作用 (RMI core complex/MM2 interaction) 的选择性抑制剂，其 IC50 值为 36 μM。PIP-199 可用于耐受肿瘤对 DNA 交联化疗药物的增敏研究。

PIP-199

PIP-199 Chemical Structure

CAS No. : 622795-76-0

规格 价格 是否有货
5 mg ￥4500 询问价格 & 货期
10 mg ￥7700 询问价格 & 货期

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PIP-199 相关产品

•相关化合物库:

  • Bioactive Compound Library Plus
  • Cell Cycle/DNA Damage Compound Library
  • Anti-Cancer Compound Library
  • Anti-Aging Compound Library
  • Anti-Lung Cancer Compound Library

生物活性

PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1].

IC50 & Target

IC50: 36 μM (RMI core complex/MM2 interaction)[1]
体外研究
(In Vitro)

MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM)[1].
Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies[1].
Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents[1].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

456.54

Formula

C27H28N4O3
CAS 号

622795-76-0
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Andrew F. Voter, et al. A high throughput screening strategy to identify protein-protein interaction inhibitors that block the Fanconi anemia DNA repair pathway. J Biomol Screen. 2016 Jul; 21(6): 626–633.

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