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sulfo-SPDB-DM4
sulfo-SPDB-DM4 是 ADC 的一部分，由 maytansinebased payload (DM4，一种微管抑制剂) 与 sulfo-SPDB 连接而成。
sulfo-SPDB-DM4 Chemical Structure
CAS No. : 1626359-59-8
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 1 mg | ￥17000 | 询问价格 & 货期 | |
| 5 mg | ￥51000 | 询问价格 & 货期 | |
| 10 mg | ￥86000 | 询问价格 & 货期 | |
| 25 mg | ￥160000 | 询问价格 & 货期 | |
| 50 mg | ￥250000 | 询问价格 & 货期 | |
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| 生物活性 |
sulfo-SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker. |
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| IC50 & Target |
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| 体外研究 (In Vitro) |
DM4, a structural analogue of maytansine, is a new thiol-containing and potent maytansinoid. DM4 is a cytotoxic maytansinoid drug. It is synthesized in order to link maytansinoids to antibodies via disulfide bonds. Maytansinoids inhibit tubulin polymerization and microtubule assembly and enhance microtubule destabilization, so there is potent suppression of microtubule dynamics resulting in a mitotic block and subsequent apoptotic cell death[1]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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| 分子量 |
1075.66 |
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| Formula |
C46H63ClN4O17S3 |
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| CAS 号 |
1626359-59-8 |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
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| 参考文献 |
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