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Dxd-d5 (Synonyms: Exatecan-d5 derivative for ADC)
Dxd-D5 (Exatecan-D5 derivative for ADC) 是 Dxd 的氘代物。Dxd 是一种有效的 DNA topoisomerase I 抑制剂,IC50 值为 0.31 μM,可用作靶作用于 HER2 的抗体偶联药物 ADC (DS-8201a) 的有效载荷。
Dxd-d5 Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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1 mg | ¥14500 | In-stock | |
5 mg | ¥40000 | In-stock | |
10 mg | ¥66500 | In-stock | |
50 mg | 询价 | ||
100 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
Dxd-D5 (Exatecan-D5 derivative for ADC) is a deuterium labeled Dxd. Dxd is a potent DNA topoisomerase I inhibitor, with an IC50 of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) [1]. |
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IC50 & Target |
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体外研究 (In Vitro) |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[2]. 上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
498.51 |
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Formula |
C26H19D5FN3O6 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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溶解性数据 |
In Vitro:
DMSO : 100 mg/mL (200.60 mM; ultrasonic and warming and heat to 60°C) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |
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参考文献 |
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