KN-92 phosphate | whatman (沃特曼)

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KN-92 phosphate 纯度: 99.94%

KN-92 phosphate 是 KN-93 的非活性衍生物，不具有 CaM 激酶抑制活性。KN-92 phosphate 可作为对照化合物用于阐明 KN-93 的拮抗活性。KN-93 可渗透细胞，可逆和竞争性的 CaMKII 抑制剂。

KN-92 phosphate Chemical Structure

CAS No. : 1135280-28-2

规格	价格	是否有货
10 mM * 1 mL in DMSO	￥2690	In-stock
2 mg	￥1633	In-stock
5 mg	￥2450	In-stock
10 mg	￥3380	In-stock
50 mg	￥9850	In-stock
100 mg		询价
200 mg		询价

* Please select Quantity before adding items.

KN-92 phosphate 相关产品

•相关化合物库:

Bioactive Compound Library Plus
Kinase Inhibitor Library
Anti-Cancer Compound Library

生物活性

KN-92 phosphate is an inactive derivative of KN-93, without CaM kinase inhibitory activity. KN-92 phosphate is intended to be used as a control compound in studies designed to elucidate the antagonist activities of KN-93. KN-93 is a cell-permeable, reversible and competitive CaMKII inhibitor^[1]^[2].

体外研究
(In Vitro)

KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50μM; 24 hours) is ineffective in blocking cell growth^[2].
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduced the expression of p53 and p21^[2].

上海金畔生物科技有限公司 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Human hepatic stellate cells (LX-2)
Concentration:	5-50 μM
Incubation Time:	24 hours
Result:	Ineffective in blocking cell growth.

分子量

554.98

Formula

C₂₄H₂₈ClN₂O₇PS

CAS 号

1135280-28-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 100 mg/mL (180.19 mM; Need ultrasonic)

H₂O : 0.73 mg/mL (1.32 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8019 mL	9.0093 mL	18.0187 mL
5 mM	0.3604 mL	1.8019 mL	3.6037 mL
10 mM	0.1802 mL	0.9009 mL	1.8019 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (4.50 mM); Clear solution

此方案可获得 ≥ 2.5 mg/mL (4.50 mM，饱和度未知) 的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明

*以上所有助溶剂都可在上海金畔生物科技有限公司网站选购。

参考文献

[1]. Smyth JT, et al. Inhibition of the inositol trisphosphate receptor of mouse eggs and A7r5 cells by KN-93 via a mechanism unrelated to Ca2+/calmodulin-dependent protein kinase II antagonism. J Biol Chem. 2002;277(38):35061-35070.

[2]. An P, et al. KN-93, a specific inhibitor of CaMKII inhibits human hepatic stellate cell proliferation in vitro. World J Gastroenterol. 2007;13(9):1445-1448.

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